A theory so far....

Sampson Onwuka

In keeping to themes of 2014 August 12th, and the injunctions justifying great periods in the annals of world history, we can begin from May 15, 2015, to attempt a public analyses of the theories involving HIV and how it can finally be set aside for all times. Drawn from the piece from last year, we can recall that the emphasis on Polio Virus was the author’s systematic strategy in analyzing some of the gaps and deficiencies that bar the final solutions for Interleukin-2 virus and HIV. The author classified HIV as a blood cancer was no new article of faith, it was driven perhaps by lateral arguments on Lentivirus and the slow Visna virus some of the slow virus is perhaps due to the origins of the strains. One of the flim-flam from Robert Gallo is the attempt at correlating Cancer or Oncogenic viruses and HIV, that is the rate at which Oncogenic and Lentiviruses such Visna are considered slow virus and may have a few things to do with HIV AIDS. Put it differently, it is important to argue that the presence of thymus as a sugar complex and its complication and its relations to CD4 – makes it clear that the penetration of the human immune system by locally manufactured foreign virus (HIV) and the gradual evolution of a prophage whose life retains a DNA from previous reproductive process gives us the impression of Immune Deficiency that is determined by the ability of existing DNA and genetic substance – Cytosine, Guanine, Adenine and Thymine to thrive, differently. A recent account on this episode can be reached through; Genetics Home Reference that “DNA bases pair up with each other, A with T and C with G, to form units called base pairs. Each base is also attached to a sugar molecule and a phosphate molecule. Together, a base, sugar, and phosphate are called a nucleotide.” The book explains the particular kind of sugar dissolving bacteria that can be considered – part and central to the breakdown and replication of the base pair – and the role of Amino Acid in genetic transfer based on the work of Avery Oswald, Alfred and Martha Chase (using bacteria) and well received as experiment, suggesting that E. Coli transduce feed through sugar. What is the result of an experiment by French scientist Andrew Lwdolf, Jacque Monod and Maurice Francoise, especially Jacque Monod, who placed several emphasis on E.coli and its adaptive enzyme to sugar and so on? The result is that we can attempt to connect E.coli to enzymes that can affect a complex, and may alter a body’s immune system. Not enough have changed since these theories, especially how a base, sugar, and phosphate define nucleotide, how it illustrates the role of Thymus in rebuilding human DNA given its relatively weak bonding and how thymus forms the attachment, leading to a regeneration of life. One of such example is the case of Bromide-5-Methylation, responsible for all kinds of adaptation to the body and to the new realities of foreign antigen – usually part of the digestive system is achieved by Thymus or CD4s, which link the DNA of foreign intruder to human DNA thereby hosting immune response. Naturally the body has no mean defensive device saving for its reaction to intrusion – mainly due to the structure of human DNA that is perpetually in such motion that new antigen tend to interfere, tend to delay information through RNA, and in the end, alter the dynamics of the body. We are naturally sick from any hint of interference to human system – environment plays a part and the body releases enzyme or proteins to auto repair by acting as bi-product for the gaps in RNA communication. An elementary knowledge of the role of proteins, vitamins and nutrients is that they help to replenish the body by introducing extra help which weaken DNA bonds and in such cases thymus can canter to.

 

In one recent book by Leanne K. Currie-McGhee (2008) that “HIV replicates itself by inserting its RNA into a cell’s DNA. When the cell divides, a new copy of the Virus is produced. This increases the amount of HIV in a person. HIV then attacks CD4 cells, also known as T Cells. T Cells are immune cells that fight off illnesses. When HIV hijacks these cells, the body loses its ability to fight off illnesses. AZT blocks the replication of HIV. As a result, AZT decreases the amount of HIV in the body and increases a person’s healthy CD4 cell count.” While this is a good summary of the operational dynamics of HIV, it hardly tells any stories about human health, and does not do much good to any scientist interest in exploring new ideas. From her book we learn the current classes of HIV medications; Non-nucleoside reverse transcriptase (NNRTIs), (2) Non-nucleoside reverse transcriptase inhibitors (NRTIs), (3) Protease Inhibitors and (4) Fusion Inhibitors, all of which work to perform one function; stop HIV multiplication. She then adds the struggling function of the various groups of medication that “NNRTIs and NRTIs are both reverse transcriptase inhibitors that stop viral RNA from being turned into DNA. The nucleoside and non-nucleoside reverse transcriptase inhibitors target slightly different parts of the enzyme. Protease inhibitors prevent the HIV Virus from forming mature Virions. Fusion inhibitors stop HIV from actually entering CD4 cells.” Such summary of the whole process is acceptable in understanding the current medication with Virus, but does not nearly open the discussion to further treatment, it does not nearly deal with the issues arising from knowledge on H.I.V. In reality, there is more to be desired about the patient to patient experience which HIV communities can offer, for instance the impact of new but also old drugs on these patient, and why these drugs offer a future that encourages replications if not control at the virions level, why there are problems of handling the virus. Put it bluntly, the emphasis on cocktails and its combinations are attempt at final cases of the HIV patient, whereas the main attention is not only the mode of transmission or the pathology of virus, rather, why HIV virus only affect human beings.  

 

There are so much that enter public discussion on HIV, but half of the standard procedure for handling the virus – beginning with prescription for HIV Patient cover two major categories, the Nuke and None Nuke and in the words of Magic Johnson, there are more than 22 specialist products on HIV, including AZT – (Zidovudine or Azidothymidine) approved in 1987 by FDA, used on farm animals, primarily popular in the 90’s, popular in New York and renown for poisonous, and remained for a long time the major problem with Food and drug administration. But from the sciences involved in understanding HIV and the treatment that followed, these products types are probably similar in essence and cover at least three major aspects of the HIV treatment, from inhibiting the growth of the Virus to the aiding the CD4s in its attempt in reducing the efficacy of the Viral load at any level of its existence. The last basic determinative of the designer drug is suffocating the maturity of the virions into adult virus – delaying its destructive adult stages. Whatever may be the nature of the Virus and the attention of drug companies, the attempt at inhibiting the progress of the Virus and the use of AZT in normalizing the function of the body or hormones in the body and its CD4 responses will only delayed the end. It is the expectation of medical profession that if the Baby Virions are kept at the lows level of maturity, it may prove less destructive to the system or the body, proving in certain cases that the drug may lengthen the life of a victim. The earliest patients were known not to have died from the virus itself suggesting to scientist that perhaps that preventing the HIV from profligate activity was more rewarding than the cure. What exactly killed HIV patient – assuming the HIV was not lethal and the virus slow in its destruction? The patient dies from other infections other than self was one of the central puzzles that defied the earliest years of the pandemic.  The challenge is how to overcome the pandemic and to end the most demanding infection other than cancer. There are great many stories regarding the behavior of AIDS patient. Some of the dread over HIV was due to its presence in “FECES – Nasal fluid”, in the Saliva of the patient, including – ‘sweat, tears, urine’, some of the cases of the dread involve use of “Urine – Vomit, “Vomit – slight chance with blood on it”, and other body fluids (1) Amniotic fluids, (2) “cerebrospinal fluid” and (3) synovial fluid”.

 

To manage the cycle of information which does not die easy – especially with the pandemic that took American by storm, some of the early claims about the earlier (viruses) or infections need to be drawn, part of which is how and to what extent the virus defies the system. Perhaps in this account, some of the general definition on the virus leads us to emphasize the commitment of its earliest scientist to finding a cure. There is nothing displaced about champions such as Watson and Crick, for instance, these men were alive at the time of the pandemic and struggled to provide the answer but how the virus took a shine off their brilliance has not been well discussed, above all, how some of their drives with HIV provided paved the way for other experiments. The shift in the focus of the study of HIV is perhaps due to other civil strife. It is worth the time to return to the early years of the pandemic and pull straws on what the Scientist did, when and how. Accounts of the DNA discoveries (A) James Watson (b) Francis Crick is still popular – so also the story of the Alpha Helix, the accounts on Haemoglobin and the accounts of Linus Pauling including his work on Sickle Cells, HPA 22 Insulin (Diabetes), Insulin – including the work of Jacques Monod and his E. Coli Phage Diabetes – some of which is reach back to Oswald Avery (S-strain, Streptococcus, E Coli Phage Virus,..) part of which is the story of Vaccination  leading in case to John Enders, James Salk, Albert Sabin, Tuberculosis….The standard techniques for studying new pandemics is not unknown, but the relevant questions are still useful, that is, what happens or happened during periods of epidemics such as flu-virus? How does that relate to pandemic such as EBV or in our studies, HIV? How does the story of Polio and period of cold virus prove a point of interest for those who ventured into Africa in search of the origins of HIV? Since the scientist driven from their home land, and write back to the States, where these scientist interested in major themes on HIV or he experiment with vaccination proved a point for evolution and studies in anthropology. HIV is argued to have origins in other creatures and remains for many of us a point of dissent. The theory has political stay, and there are few believers in that such theories on Zaire strain, may be correct, fewer will accept that perhaps the African dissent on the origins of HIV is perhaps misleading - if not untrue. The role of enzyme in the blood is important – the role of oxygen in the blood is also important, but the link to thymus and link with E Coli phage bacteria or sugar mulching prophage may yet gain acceptance but it is part of the reasons why there is blood thinning in the latter stages of the patient’s life. The profligate behavior of E.coli naturally involves the reduction of sugar – they feed on sugar molecules thereby preventing the normal molecule structure of the Carbon (  ) DNA especially thymus.